Marco Polo travels from Venice to Peking, where he quickly discovers spaghetti and gunpowder and falls in love with the Emperor's daughter. The Emperor Kublai Khan is a kindly fellow, but his evil aide Ahmed wants to get rid of Kublai Khan so he can be emperor, and to get rid of Marco Polo so he can marry the princess. Ahmed sends Marco Polo to the West to fight barbarians, but he returns just in time to save the day.

When the government opens up the Oklahoma territory for settlement, restless Yancey Cravat claims a plot of the free land for himself and moves his family there from Wichita. A newspaperman, lawyer, and just about everything else, Cravat soon becomes a leading citizen of the boom town of Osage. Once the town is established, however, he begins to feel confined once again, and heads for the Cherokee Strip, leaving his family behind. During this and other absences, his wife Sabra must learn to take care of herself and soon becomes prominent in her own right.

After his ship goes down, Edward Parker is rescued at sea. Parker gets into a fight with Captain Davies of the Apia and the Captain tosses him overboard while making a delivery to the tiny tropical island of Dr. Moreau. Parker discovers that Moreau has good reason to be so secretive on his lonely island. The doctor is a whip-cracking task master to a growing population of his own gruesome human/animal experiments. He does have one prize result, Lota the beautiful panther woman. Parker's fortunes for escape look up after his fiancée Ruth finds him with the help of fearless Captain Donohue. However, when Moreau's tribe of near-humans rises up to rebel, no one is safe...